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目的探讨大剂量米非司酮联合米索前列醇在16~24周妊娠引产中的应用价值。方法选取石家庄市鹿泉区妇幼保健院2012年6月-2014年6月收治的孕16~24周要求终止妊娠的患者200例,随机分为观察组和对照组各100例。观察组给予大剂量米非司酮联合米索前列醇终止妊娠,对照组给予常规剂量米非司酮联合米索前列醇终止妊娠。观察2组宫缩开始时间、宫颈成熟度、排胎时间、产妇产后2h出血量、引产成功率及不良反应发生情况。结果观察组的宫缩开始时间、排胎时间均短于对照组,宫颈成熟度Bishop评分高于对照组,产妇产后2h出血量少于对照组,引产成功率高于对照组,差异均有统计学意义(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论大剂量米非司酮联合米索前列醇终止16~24周妊娠流产效果较好,可缩短流产时间,安全有效。
Objective To investigate the value of high-dose mifepristone combined with misoprostol in induction of labor during 16-24 weeks gestation. Methods 200 cases of patients requiring termination of pregnancy during 16-24 weeks of pregnancy in Luquan District Maternity and Child Care Hospital of Shijiazhuang from June 2012 to June 2014 were randomly divided into observation group and control group with 100 cases each. The observation group was given high dose of mifepristone combined with misoprostol to terminate the pregnancy, and the control group was given normal dose of mifepristone combined with misoprostol to terminate the pregnancy. The initial contractions, the degree of cervical maturation, the time of rowing, the amount of bleeding 2 hours after delivery, the success rate of induction and the incidence of adverse reactions were observed. Results The observation group had shorter contraceptive time and rowing time than the control group. The Bishop score of cervical maturity was higher than that of the control group. The amount of bleeding after 2 hours of labor was less than that of the control group, and the success rate of induction of labor was higher than that of the control group Significance (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion The high dose of mifepristone combined with misoprostol is effective in terminating 16-24 weeks of abortion, which can shorten the time of abortion and be safe and effective.