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目的探讨神经生长因子(NGF)金路捷添加治疗对儿童难治性癫痫的近、远期疗效及生活质量的影响。方法收集难治性癫痫患儿107例,包括全身性发作、部分性发作和癫痫性痉挛各42、48、17例。维持原抗癫痫方案不变,添加金路捷4500U qd肌注4周。对患儿保持随访1年,采用儿童癫痫生活质量量表(QOLCE)进行评估。结果治疗开始3个月时癫痫治疗显效率16.8%,1年时显效率为32.3%,远期疗效优于近期疗效(χ~2=5.530,P=0.019)。金路捷对各种发作类型疗效无明显差异(P>0.05)。治疗1年后,患儿癫痫儿童生活质量评分(QOLCE)较治疗前明显升高(P=0.027)。结论金路捷添加治疗对儿童难治性癫痫可能存在一定疗效,远期疗效优于近期疗效,并且可改善患儿生活质量。
Objective To investigate the effect of Nerve Growth Factor (NGF) add-on therapy on short-term and long-term effects and quality of life in children with refractory epilepsy. Methods A total of 107 children with intractable epilepsy were enrolled in this study, including 42, 58 and 17 cases of generalized seizures, partial seizures and epileptic seizures. Maintain the original anti-epilepsy program unchanged, add Jin Lu Jie 4500U qd intramuscular injection for 4 weeks. Children were followed up for 1 year, using the Children’s Epilepsy Quality of Life Scale (QOLCE) for evaluation. Results The effective rate of epilepsy was 16.8% at 3 months after treatment, and 32.3% at 1 year. The long-term effect was better than the short-term effect (χ ~ 2 = 5.530, P = 0.019). Jin Lu Jie efficacy of various types of seizures no significant difference (P> 0.05). After 1 year of treatment, QOLCE in children with epilepsy was significantly higher than that before treatment (P = 0.027). Conclusion Jin Lu Jie added treatment of children with intractable epilepsy may have some effect, long-term efficacy is better than the recent efficacy, and can improve children’s quality of life.