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为探讨谷氨酸(Glu)在化脑时的变化,对34例颅内感染患儿,以液相色谱法测定其CSF中Glu水平。结果表明化脑患儿CSF谷氨酸显著高于对照组和病毒脑患儿(P<0.01);病毒脑患儿与对照组相比,Glu水平无差异(P>0.05);有惊厥史的病毒脑CSF中Glu高于无惊厥史的病脑,但两者差异不显著。分析认为影响CSF中Glu浓度的因素有疾病的种类、有无惊厥及病情轻重。应探讨Glu受体拮抗剂和钙离子通道阻滞剂在颅内感染性疾病中的应用。
In order to explore the changes of glutamate (Glu) in the brain, 34 children with intracranial infection were assayed for CSF Glu levels by liquid chromatography. The results showed that the level of CSF glutamate in children with brain injury was significantly higher than that in the control group and the virus brain (P <0.01). There was no difference in Glu levels between the children with virus brain disease and the control group (P> 0.05) Glu in brain CSF was higher than that in brain without convulsion, but the difference was insignificant. Analysis of the factors that affect the concentration of Glu in CSF have the type of disease, with or without convulsions and severity. Glu receptor antagonists and calcium channel blockers should be explored in the application of intracranial infectious diseases.