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目的调查我院医务人员接种HINI后的不良反应(ADR)发生情况,探讨其临床接种安全性。方法随机选择我院2011年1月至2012年1月间,接种过HINI疫苗的医务人员210例,采用问卷形式对其进行调查,记录接种人员基本情况、注射H1N1后ADR发生率、临床表现、反应程度、出现、持续及转归时间等,并对其进行统计分析。结果总的ADR发生例数和发生率为43例23.89%;女性ADR发生例数和发生率为25例28.40%,显著高于男性的18例15.56%(P<0.05);不同年龄段医务人员接种H1N1 ADR应发生率不存在显著差异(P>0.05);不良反应平均出现时间10.3±5.7h,平均持续时间25.6±7.6h。结论接种甲型H1N1流感疫苗安全性较高,不良反应短而轻,可用于医务人员预防及疫情应急接种。
Objective To investigate the incidence of adverse reactions (ADR) after HINI vaccination in our hospital and discuss the safety of clinical inoculation. Methods A total of 210 medical staff were vaccinated with HINI vaccine from January 2011 to January 2012 in our hospital. The questionnaires were used to investigate the basic situation of vaccination personnel, the incidence of ADR after injection of H1N1, clinical manifestations, The degree of reaction, appearance, duration and time of return, etc., and statistical analysis. Results The total number and incidence of ADR cases were 43 and 23.89%, respectively. The incidence and incidence of female ADR were 28.40% in 25 cases and 15.56% in 18 cases of men (P <0.05). Medical staff of different ages There was no significant difference in the incidence of H1N1 ADR vaccination (P> 0.05). The average incidence of adverse reactions was 10.3 ± 5.7 h with an average duration of 25.6 ± 7.6 h. Conclusion Influenza A (H1N1) vaccination is safe, with short and light side effects. It can be used for prevention of medical staff and emergency vaccination.