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目的检测布鲁菌病患者血清中可溶性程序性死亡蛋白1(sPD-1)和配体sPD-L1、Th1型细胞因子γ干扰素(IFN-γ)、Th2型细胞因子白细胞介素4(IL-4)的变化。方法选取56例布鲁菌患者与48例健康志愿者,采用ELISA检测血清中sPD-1和sPD-L1的水平,用流式微珠阵列技术(CBA)法检测血清中Th1/Th2细胞因子水平,并对37例布鲁菌病患者进行追踪随访检测。结果与正常对照组相比,布鲁菌病患者血清中sPD-1和sPD-L1及IL-4水平均明显升高,而IFN-γ水平明显降低;37例随访患者治疗后血清中sPD-1和sPD-L1及IL-4水平较治疗前明显降低,而IFN-γ的水平较治疗前明显增高。结论布鲁菌患者血清中sPD-1、sPD-L1水平升高。
Objective To detect the levels of soluble programmed-death protein 1 (sPD-1), sPD-L1, Th1-type cytokine interferon (IFN-γ) and Th2 cytokine interleukin-4 (IL- -4) changes. Methods 56 brucellosis patients and 48 healthy volunteers were enrolled in this study. Serum levels of sPD-1 and sPD-L1 were detected by ELISA. Th1 / Th2 cytokines were measured by flow cytometry (CBA) 37 cases of brucellosis patients were followed up. Results Serum levels of sPD-1, sPD-L1 and IL-4 in brucellosis patients were significantly higher than those in normal control group, while the levels of IFN-γ were significantly decreased in the patients with brucellosis. Serum levels of sPD- 1 and sPD-L1 and IL-4 levels were significantly lower than before treatment, while the level of IFN-γ was significantly higher than before treatment. Conclusion Serum sPD-1, sPD-L1 levels in patients with brucellosis increased.