论文部分内容阅读
目的:探讨A型肉毒毒素(botulinumtoxintypeA,BTX-A)对上运动神经元损伤后肢体肌肉痉挛的治疗价值及其剂量影响。方法:选择48例上运动神经元损伤患者采用肉毒毒素A电刺激引导下局部肌肉注射治疗肌痉挛,其中把小腿三头肌、肱二头肌、屈指肌随机分成高低两个剂量组,观察剂量不同对疗效的影响,同时对所有患者制订注射后的目标,观察其达标情况。结果:肉毒毒素A注射后肌肉张力明显降低(P<0.05),但在小腿三头肌、肱二头肌及屈指肌群中均未发现明显的量效关系,各配对大小剂量组肌张力评分差异无显著性意义(P>0.05);患者功能显著改善,康复目标总达标率为70.4%,肉毒毒素对上肢的粗大运动及下肢的步行功能的改善效果明显,而对手的精细活动功能的恢复效果欠佳。结论:肉毒毒素A对缓解上运动神经元损伤后的肢体肌肉痉挛,提高其生活自理能力及运动功能疗效显著,肉毒毒素作用的量效关系尚有待确认。
Objective: To investigate the therapeutic value and dose effect of botulinum toxin type A (BTX-A) on muscle spasm of upper extremity after motor neuron injury. Methods: Forty-eight patients with upper motor neuron injury were treated with local intramuscular injection of botulinum toxin A (EAI) to treat muscle spasm. The triceps, biceps and flexor muscles were randomly divided into two groups, Different doses of the effect of the effect, at the same time for all patients to develop injection goals, to observe its compliance. Results: Muscle tension was significantly decreased after botulinum toxin A injection (P <0.05), but no significant dose-response relationship was found in the triceps, biceps and flexor muscles of the calf. The muscle tension There was no significant difference between the two groups (P> 0.05). The patient’s function improved significantly, and the total compliance rate of rehabilitation goal was 70.4%. The effect of botulinum toxin on the upper limb’s gross function and lower limb’s walking function was obvious. Poor recovery. CONCLUSION: Botulinum toxin A can relieve muscle spasm of limbs after upper motor neurons injury and improve their self-care ability and motor function. The dose-response relationship of botulinum toxin has yet to be confirmed.