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应用放射受体分析法测定４０例子宫肌瘤患者子宫肌瘤、肌肉组织雌激素受体（ＥＲ）、孕激素受体（ＰＲ）的含量，月经周期根据月经史及子宫内膜组织相来判断，比较两种组织ＥＲ、ＰＲ含量与月经周期及子宫内膜组织相的关系。结果：子宫肌瘤组织的ＥＲ、ＰＲ含量高于同一子宫正常肌层的含量（Ｐ＜０．０５）；子宫肌瘤与肌肉两种组织中ＥＲ含量在子宫内膜增殖期高于分泌期（Ｐ＜０．０２５，Ｐ＜０．０５），ＰＲ含量分泌期高于增殖期（Ｐ＜０．０２５）。２３例有正常月经周期者，１５例与子宫内膜组织相符合，８例与子宫内膜组织相不符合。１５例无正常月经周期者，子宫内膜组织相多为增殖期改变，占８０％。提示：子宫肌瘤的发生、发展与雌、孕激素及其受体含量有关，孕激素在肿瘤发生、发展中可能起协同作用，提示抗孕激素治疗子宫肌瘤的可能性。
Radiographic assay was used to determine the content of estrogen receptor (ER) and progesterone receptor (PR) in uterine fibroids and uterine fibroids in 40 patients with uterine fibroids. The menstrual cycle was determined according to the menstrual history and endometrial phase The ER, PR contents in the two tissues were compared with those in the menstrual cycle and endometrial tissues. Results: The content of ER and PR in uterine myoma was higher than that in normal uterus (P <0.05). The content of ER in both uterine leiomyoma and muscle in endometrium was higher than that in secretory phase P <0.025, P <0.05). The PR level was higher in secretory phase than in proliferative phase (P <0.025). 23 cases had normal menstrual cycle, 15 cases were consistent with endometrial tissue, and 8 cases were not consistent with endometrial tissue. 15 cases of normal menstrual cycle, endometrial tissue mostly proliferative phase change, accounting for 80%. Tip: The occurrence and development of uterine fibroids and estrogen and progesterone and its receptor content, progesterone in the tumor occurrence and development may play a synergistic role, suggesting that the possibility of anti-progesterone treatment of uterine fibroids.