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目的:观察戊己丸传统汤剂、复方及配方颗粒剂镇痛、止泻和抗急性胃溃疡作用,比较不同剂型的药效差异。方法:将小鼠或大鼠分为对照组、阳性药组和戊己丸传统汤剂、复方及配方颗粒剂高、中、低剂量组(小鼠4.0,2.0,1.0 g·kg-1;大鼠2.8,1.4,0.7 g·kg-1),ig给药3~8 d,制作乙酸致痛、番泻叶致泻及无水乙醇致大鼠急性胃溃疡模型,观察戊己丸汤剂、复方及配方颗粒剂的镇痛、止泻和抗急性胃溃疡作用。结果:与对照组比较,戊己丸汤剂、复方及配方颗粒4.0,2.0,1.0 g·kg-1能明显抑制乙酸引起的小鼠扭体反应;减少番泻叶引起的小鼠腹泻次数;其2.8,1.4,0.7 g·kg-1显著减轻无水乙醇导致的大鼠急性胃黏膜损伤。结论:戊己丸传统汤剂、复方及配方颗粒剂均有较好的止痛、止泻和抗急性胃溃疡作用,药效无明显差异。
OBJECTIVE: To observe the analgesic, antidiarrheal and anti-acute gastric ulcer effects of traditional decoction of Wu-hui Wan, compound and formula granule, and to compare the difference of pharmacodynamics of different formulations. Methods: The mice or rats were divided into the control group, the positive drug group, the traditional decoction of Wuji Pills, the high, medium and low dose groups of compound and formula granules (mice 4.0, 2.0, 1.0 g · kg -1; Rats 2.8,1.4,0.7 g · kg-1), ig administration for 3 ~ 8 d, made acetic acid induced pain, senna induced diarrhea and ethanol-induced acute gastric ulcer model in rats, observation Wujiwan decoction , Compound and formula granule analgesic, antidiarrheal and anti-acute gastric ulcer effect. Results: Compared with the control group, Wuxu pill decoction, compound and formula granule 4.0, 2.0, 1.0 g · kg-1 can significantly inhibit acetic acid-induced writhing reaction in mice; reduce the number of mice diarrhea caused by senna; Its 2.8,1.4,0.7 g · kg-1 significantly reduced acute gastric mucosal injury induced by ethanol in rats. Conclusion: The traditional decoction of Wuji Wan, compound and formula granule have good analgesic, antidiarrheal and anti-acute gastric ulcer effect, no significant difference in efficacy.