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目的观察纳洛酮不同给药方法治疗重度急性酒精中毒的疗效及安全性。方法将重度急性酒精中毒患者127例分为X组40例、Y组44例和Z组43例。采取3种不同的给药方案,观察三组患者清醒时间及不良反应情况。结果 X组、Y组和Z组患者的清醒时间逐渐缩短,不良反应发生率依次升高,各组间比较差异均有统计学意义(P<0.05)。结论大剂量纳洛酮治疗重度急性酒精中毒安全有效,清醒时间短,值得推广,持续给药不良反应更少。
Objective To observe the efficacy and safety of different administrations of naloxone in the treatment of severe acute alcohol poisoning. Methods A total of 127 patients with severe acute alcoholism were divided into X group (40 cases), Y group (44 cases) and Z group (43 cases). Three different dosing regimens were taken to observe the awake time and adverse reactions of the three groups. Results The awake time of patients in group X, group Y and group Z gradually shortened, and the incidence of adverse reactions increased in turn, with statistical significance (P <0.05). Conclusion High-dose naloxone is safe and effective in the treatment of severe acute alcohol poisoning. The awake time is short and worthy of promotion. Adverse reactions with continuous administration are fewer.