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1例64岁男性患者因甲状腺功能亢进症接受甲巯咪唑(10 mg,2次/d口服)和普萘洛尔(10 mg,3次/d口服)治疗。5 d后患者出现皮疹伴瘙痒,自行服用氯雷他定后症状好转。第25天甲巯咪唑剂量调整为10 mg,3次/d口服;普萘洛尔调整为20 mg,3次/d口服,并行保肝治疗。调整剂量后第9天患者出现间歇性、游走性关节疼痛和关节活动受限,第11天停用甲巯咪唑并给予美洛昔康。停用甲巯咪唑后2周患者关节疼痛明显好转,无关节活动受限。
One 64-year-old male patient was treated with methimazole (10 mg, 2 times daily) and propranolol (10 mg, 3 times daily) for hyperthyroidism. 5 days after the patient with rash and itching, self-medication loratadine symptoms improved. On the 25th dose of methimazole was adjusted to 10 mg orally 3 times / d; propranolol was adjusted to 20 mg orally 3 times / d in parallel with liver protection. On day 9 after dose adjustment, the patient experienced intermittent, migratory joint pain and restricted joint activity. Methlimazole was discontinued on the 11th day and meloxicam was given. 2 weeks after the withdrawal of methimazole patients with joint pain was significantly improved, no joint activity restriction.