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通过人胚胎雌激素受体(ER)测定发现,多数人胚器官均有ER分布,包括子宫、肝和少数脾、胃、肺。随胚龄增大而ER增加的靶器官有子宫、卵巢、睾丸及一些非靶器官,如胃、上消化道系统;随胎龄增大而递减的有下消化道。肺、心、脑和淋巴组织则呈持续低水平。 早胚ER阳性细胞(A、B、C型)计数高于胚胎后期。A、B型细胞至5月时降至低谷,6个月时又增高。在非靶器官中,C、D型细胞在4个月时为最低点,而D细胞在子宫、睾丸、和肝中很快又高。提示ER在人胚发育和分化过程中有一定意义。
By human embryonic estrogen receptor (ER) determination found that most human embryonic organs ER distribution, including the uterus, liver and a few spleen, stomach, lung. With increasing age and ER increased target organ uterine, ovarian, testicular and some non-target organs, such as the stomach, upper digestive tract system; decreased with increasing gestational age and lower gastrointestinal tract. Lung, heart, brain and lymphoid tissue showed a continuous low level. Early embryo ER positive cells (A, B, C type) count higher than the late embryo. A, B-type cells down to the trough in May, 6 months and then increased. In non-target organs, C and D cells are the lowest at 4 months, while D cells are fast and high in the uterus, testis, and liver. Tip ER in human embryonic development and differentiation have some significance.