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合理的联合用药,能提高疗效,减少副作用。否则,可引起各种不良反应,甚至造成严重恶果。据报道,同时接受5种以下药物的病人,其药物反应发生率为18.6%。而同时服用6或6种以上药物者,其反应发生率可上升至81.4%。为了避免合并用药产生不利的干扰,获得预期效果,医务人员必须对药物在体内相遇时可能引起的相互作用及其机理有较深入的了解,以确保用药安全有效。药物进入体内不利的相互作用,可表现在药物到达作用部位的效应量,即药物动力学
A reasonable combination of medication, can improve the efficacy and reduce side effects. Otherwise, it can cause various kinds of adverse reactions, and even cause serious consequences. It is reported that patients receiving 5 or less drugs at the same time, the incidence of drug reactions was 18.6%. At the same time take 6 or more than 6 kinds of drugs, the response rate can be increased to 81.4%. In order to avoid adverse interference caused by the combination of drugs, to obtain the desired effect, medical staff must interact with the drug in the body may have a more understanding of the interaction and its mechanism to ensure that the drug is safe and effective. Adverse drug interactions into the body, can be expressed in the role of the drug to reach the site of action, that is, pharmacokinetics