论文部分内容阅读
肾小球硬化是糖尿病肾病的重要特征。近年发现转化生长因子β1在糖尿病肾小球硬化的发生机制中起着重要作用,是多种致病因子作用的最终途径,通过促进肾脏系膜细胞肥大和细胞外基质产生,抑制细胞外基质降解,损害足细胞,参与糖尿病肾小球硬化的发生和发展。研究转化生长因子β1及其上调的影响因素和干预措施,有助为糖尿病肾小球硬化的防治提供新的理论基础和临床指导。
Glomerulosclerosis is an important feature of diabetic nephropathy. In recent years, it has been found that transforming growth factor-β1 plays an important role in the pathogenesis of diabetic glomerulosclerosis and is the ultimate pathway of various causative agents. It can inhibit the degradation of extracellular matrix by promoting mesangial cell hypertrophy and extracellular matrix production , Damage podocytes, participate in the occurrence and development of diabetic glomerulosclerosis. The study of TGF-β1 and its influencing factors and interventions will help to provide a new theoretical basis and clinical guidance for the prevention and treatment of diabetic glomerulosclerosis.