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目的探讨子宫奇异型平滑肌瘤的组织形态学特征及其诊断和鉴别诊断。方法采用肉眼、光镜观察及免疫组织化学方法对22例子宫奇异型平滑肌瘤进行组织病理学分析。结果22例子宫奇异型平滑肌瘤粘膜下肌瘤6例,肌壁间肌瘤12例,浆膜下肌瘤4例;镜下部分或全部胞核奇异,双核或多核易见,其中8例偶见核分裂像(≤1个/10HPF);全部瘤细胞胞质平滑肌肌动蛋白(SMA)染色阳性,呈肌源性表达。结论子宫奇异型平滑肌瘤是一种特殊的平滑肌瘤,临床表现是良性的,容易误诊,需与平滑肌肉瘤进行鉴别。
Objective To investigate the histopathological features of uterine singular leiomyoma and its diagnostic and differential diagnosis. Methods Histopathological analysis of 22 cases of uterine myoma of leiomyoma was performed by naked eye, light microscope and immunohistochemistry. Results 22 cases of uterine myoma of submucous leiomyomas in 6 cases, 12 cases of intramural fibroids, 4 cases of subserosal fibroids; microscopy of some or all of the singular nuclei, binuclear or multinuclear, of which 8 cases Occasionally mitotic image (≤ 1 / 10HPF); all tumor cells stained smooth muscle actin (SMA) staining was myogenic expression. Conclusion Uterine leiomyoma is a special type of leiomyoma, the clinical manifestations are benign, easily misdiagnosed, need to be differentiated from leiomyosarcoma.