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目的：研究ｌ黄皮酰胺诱导麻醉大鼠海马齿状回长时程增强（ＬＴＰ）的机制．方法与结果：细胞外记录麻醉大鼠海马齿状回诱发电位．脑室注射纳洛酮１ｎｍｏｌ对其基础突触传递活动和强直刺激诱导的ＬＴＰ无影响．在ｌ黄皮酰胺之前１０ｍｉｎ脑室注射同剂量的纳洛酮，其群峰电位（ＰＳ）的幅值于脑室注射ｌ黄皮酰胺４ｎｍｏｌ后２０ｍｉｎ，５５ｍｉｎ和９０ｍｉｎ分别从１３８％±１０％，１７０％±１０％和１６９％±１２％降为１１０％±７％，１２４％±１４％和１２３％±１１％．Ｐ＜００１（ｎ＝８）．在ｌ黄皮酰胺之后１０ｍｉｎ给予同剂量的纳洛酮对ＰＳ无影响．结论：阿片受体的激活参与了ｌ黄皮酰胺对麻醉大鼠海马齿状回ＬＴＰ的诱导过程．
Objective: To investigate the mechanism of l-humectin-induced hippocampal dentate gyrus long-term potentiation (LTP) in anesthetized rats. Methods and Results: Extracellular recording of anesthetized rat hippocampal dentate gyrus evoked potentials. Intraventricular injection of naloxone 1 nmol had no effect on basal synaptic transmission and tetanic stimulation-induced LTP. L-carnitine 10min intraventricular injection of the same dose of naloxone, the peak potential (PS) in the amplitude of intraventricular l-humectin 4nmol after 20min, 55min and 90min from 138% ± 10%, respectively, 170% ± 10% and 169% ± 12% to 110% ± 7%, 124% ± 14% and 123% ± 11%. P <001 (n = 8). Naloxone given the same dose of naloxone 10min after l laccase had no effect on PS. CONCLUSION: Activation of opioid receptors is involved in the induction of L-cathepsin in the hippocampal dentate gyrus LTP of anesthetized rats.