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目的:探讨桂枝茯苓胶囊对不同类型女性不孕症患者血清细胞因子的影响。方法:对照组为健康体检女性(有生育史)20例,实验组为不孕症患者133例(服用桂枝茯苓胶囊3个月,3次/d,3粒/次):慢性盆腔炎41例,子宫肌瘤37例,子宫内膜异位症27例,多囊卵巢综合征28例。采用ELISA酶联免疫法检测两组妇女血清中IL-2、TNF-α、IFN-γ、IL-4、IL-10、IL-21的蛋白含量,采用流式细胞术检测AhCGAb、AsAb、AOAb、EMAb的阳性率,同时追踪停药6个月内的妊娠率。结果:实验组服药前血清中IL-2、TNF-α、IFN-γ、IL-21的蛋白含量及AhCGAb、AsAb、AOAb、EMAb的阳性率均明显高于对照组,差异有统计学意义(P<0.01),而IL-4、IL-10则无明显变化;实验组服药后与对照组相比各指标差异均无统计学意义(P>0.05)。各种类型不孕症患者停药6个月内的妊娠率分别为慢性盆腔炎43.90%、子宫肌瘤40.54%、子宫内膜异位症37.04%和多囊卵巢综合征32.14%。结论:桂枝茯苓胶囊可通过下调血清中IL-2、TNF-α、IFN-γ、IL-21的蛋白含量及AhCGAb、AsAb、AOAb、EMAb的阳性率在不孕症治疗中发挥作用,其作用机制有待于进一步探讨。
Objective: To investigate the effects of Guizhi Fuling capsule on serum cytokines in different types of female infertility patients. Methods: The control group consisted of 20 healthy women (with reproductive history) and 133 experimental infertile women (treated with Guizhi Fuling capsule for 3 months, 3 times / d, 3 capsules / time): chronic pelvic inflammatory disease 41 Cases, 37 cases of uterine fibroids, 27 cases of endometriosis, polycystic ovary syndrome in 28 cases. The contents of IL-2, TNF-α, IFN-γ, IL-4, IL-10 and IL-21 in sera of two groups were detected by enzyme-linked immunosorbent assay (ELISA), and the expressions of AhCGAb, AsAb and AOAb were detected by flow cytometry , The positive rate of EMAb, while tracking the pregnancy rate within 6 months of withdrawal. Results: The contents of IL-2, TNF-α, IFN-γ and IL-21 in serum before treatment in experimental group were significantly higher than those in control group (the positive rates of AhCGAb, AsAb, AOAb and EMAb were significant P <0.01), while IL-4 and IL-10 had no significant change. There was no significant difference in each index between experimental group and control group (P> 0.05). The pregnancy rates of patients with various types of infertility within 6 months were 43.90% of chronic pelvic inflammatory disease, 40.54% of uterine fibroids, 37.04% of endometriosis and 32.14% of polycystic ovary syndrome. Conclusion: Guizhi Fuling Capsule can play a role in the treatment of infertility by down-regulating the protein levels of IL-2, TNF-α, IFN-γ and IL-21 in serum and the positive rates of AhCGAb, AsAb, AOAb and EMAb Mechanism needs to be further explored.