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巴西利什曼原虫亚种引起的新大陆皮肤利什曼病,常表现为皮肤溃疡、非溃疡结节或斑块,偶而播及鼻咽粘膜,因而常需给予全身疗法。五价锑作为首选药物已有40余年历史,毒副作用甚多,大剂量可引发致死性心律失常。两性霉素B和戊烷脒毒性较大,仅用于锑剂无效的重症病例。近来,厄瓜多尔16名感染巴西利什曼原虫巴拿马亚种患者,口服甲氟喹(4.2mg/kg/日,共6天,最大剂量1.5g),8周后治愈率为100％。为证实该药
Leishmaniasis of the New World caused by Leishmania braziliensis subsp. Often manifests as skin ulcers, non-ulcer nodules or plaques, and occasionally sow nasopharyngeal mucosa and thus often requires systemic therapy. Pentacle antimony as the drug of choice for more than 40 years of history, many side effects, high doses can trigger fatal arrhythmias. Amphotericin B and pentamidine are more toxic and are intended only for severe cases of ineffective antimony agents. Recently, 16 patients infected with the Brazilian Leishmania panamaxis in Ecuador were treated with mefloquine (4.2 mg / kg / day for 6 days, maximum dose 1.5 g) orally and 100% after 8 weeks. To confirm the drug