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目的探讨血小板在椎基动脉缺血性眩晕 (VBI)发病中起的作用及血小板颗粒膜糖蛋白 (GMP140)的临床意义。方法对40例VBI病人进行血浆GMP140 浓度及血小板表面GMP140 分子数测定 ,并同时行TCD检查。结果VBI病人血浆GMP140水平显著高于对照组 (P<0.01) ,血浆GMP140的异常率为70 % ;TCD异常率为67% ;血浆GMP140测定结合TCD检测 ,异常率85%。结论VBI发病过程中存在着血小板的激活及血栓形成倾向 ;血浆GMP140 测定可以作为诊断VBI的一个客观指标 ,结合TCD检查 ,可提高对VBI的诊断水平。
Objective To investigate the role of platelet in the pathogenesis of vertebrobasilar ischemic vertigo (VBI) and the clinical significance of platelet granulocyte membrane glycoprotein (GMP140). Methods 40 cases of VBI patients were measured plasma GMP140 concentration and platelet surface GMP140 molecular number, and at the same time TCD examination. Results The plasma level of GMP140 in VBI patients was significantly higher than that in control group (P <0.01). The abnormal rate of plasma GMP140 was 70%. The abnormal rate of TCD was 67%. Plasma GMP140 assay combined with TCD showed an abnormal rate of 85%. Conclusions There is platelet activation and thrombosis tendency during the pathogenesis of VBI. Plasma GMP140 can be used as an objective index to diagnose VBI. Combined with TCD, the diagnostic value of VBI can be improved.