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临床肌注青霉素常以注射用水作稀释溶媒,由于注射部位产生难以忍受的疼痛和硬块,目前多以2％苯甲醇代替注射用水使用。苯甲醇虽有一定的止痛作用,但引起注射部位产生硬结。1983年以来,我院使用0.25％利多卡因代替苯甲醇和注射用水作青霉素肌注溶媒,使用表明这种溶媒具无疼痛,不使局部产生硬块,病人乐于接受等优点。近来已有0.25％利多卡因作青霉素无痛溶媒的报道,体外实验证明利多卡因、苯甲醇对青霉素抑菌作用和注射用水无差别,对薄层层析试验影响也无差异,而刺激性和溶血作用以利多卡因为优。呼吁以0.25％利多卡因代替苯甲醇作无痛溶媒使用。但两者对青霉素肌注后的药动学及生物利用度影响如何这一临床评价却未见报道,本文将报道这一研究结果。
Clinical intramuscular penicillin often diluted with water for injection, due to injection site intolerable pain and lumps, the current 2% benzyl alcohol instead of water for injection. Benzyl alcohol, although a certain analgesic effect, but causing injection site induration. Since 1983, our hospital used 0.25% lidocaine instead of benzyl alcohol and water for injection penicillin intramuscular injection, the use of that solvent with no pain, not to produce local lumps, the patient willing to accept other advantages. Recently 0.25% lidocaine penicillin painkillers reported, in vitro experiments show that lidocaine, benzyl alcohol on penicillin antibacterial effect and no difference in water for injection, TLC analysis of the impact of no difference, and irritation And hemolysis to lidocaine as excellent. Call for the use of 0.25% lidocaine instead of benzyl alcohol as an analgesic vehicle. However, the clinical evaluation of the effects of both on the pharmacokinetics and bioavailability of penicillin after intramuscular injection has not been reported. This article will report the results of this study.