研究非霍奇金淋巴瘤与基因重排的关系,用PCR技术检测免疫球蛋白重链基因(IgH)和T细胞受体γ基因(TCRγ)的克隆性重排。结果:①211例非霍奇金淋巴瘤患者中,IgH阳性108例,TCRγ阳性45例,双阳性12例,阴性46例;②系统观察10例患者,发现临床完全缓解时仍有5/10患者呈克隆性基因重排。结论提示,基因克隆性重排的PCR分析在非霍奇金淋巴瘤的早期诊断及评估治疗有效性方面是有用的。 The relationship between non-Hodgkin’s lymphoma and gene rearrangement was studied, and the clonal rearrangement of immunoglobulin heavy chain gene (IgH) and T cell receptor gamma (TCRγ) gene was detected by PCR. RESULTS: Of the 1211 non-Hodgkin’s lymphoma patients, 108 were IgH positive, 45 were TCRgamma positive, 12 were double positive, and 46 were negative. 2 Systematic observation of 10 patients revealed that there were still 5/10 patients with complete clinical remission. Cloning gene rearrangements. Conclusions suggest that PCR analysis of gene cloning rearrangements is useful in the early diagnosis of non-Hodgkin’s lymphoma and in evaluating the effectiveness of treatment.