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目的探讨叶酸联合维生素B6、甲钴胺、硝苯地平缓释片治疗H型高血压的临床疗效。方法选取2013年12月—2015年4月中国人民解放军第175医院收治的H型高血压患者138例,采用随机数字表法,将其分为对照组和观察组各69例。对照组患者口服维生素B6、甲钴胺、硝苯地平缓释片治疗,观察组患者在对照组的治疗基础上加服叶酸片。比较两组患者治疗前后的血压、血浆同型半胱氨酸(Hcy)水平及临床疗效。结果治疗前两组患者收缩压和舒张压比较,差异无统计学意义(P>0.05);治疗后观察组患者收缩压和舒张压低于对照组(P<0.05)。治疗前两组患者的血浆Hcy水平比较,差异无统计学意义(P>0.05);治疗后观察组患者血浆Hcy水平低于对照组(P<0.05)。观察组患者的临床疗效优于对照组(Z=6.824,P<0.05)。结论叶酸联合维生素B6、甲钴胺、硝苯地平缓释片治疗H型高血压的临床疗效确切,可以改善患者的血压水平,降低血浆Hcy水平。
Objective To investigate the clinical efficacy of folic acid combined with vitamin B6, mecobalamin and nifedipine sustained-release tablets in the treatment of Hypertension. Methods 138 patients with H-type hypertension admitted from the Chinese People’s Liberation Army 175th Hospital from December 2013 to April 2015 were randomly divided into control group and observation group (n = 69) with random number table method. Control group patients oral vitamin B6, mecobalamin, nifedipine sustained release tablets treatment group patients in the control group on the basis of the treatment plus folic acid tablets. Blood pressure, plasma homocysteine (Hcy) levels and clinical efficacy were compared between the two groups before and after treatment. Results There was no significant difference in systolic and diastolic blood pressures between the two groups before treatment (P> 0.05). After treatment, the systolic and diastolic blood pressures of the observation group were lower than those of the control group (P <0.05). There was no significant difference in plasma Hcy levels between the two groups before treatment (P> 0.05). After treatment, the plasma Hcy level in the observation group was lower than that in the control group (P <0.05). The clinical efficacy of the observation group was better than that of the control group (Z = 6.824, P <0.05). Conclusion Folic acid combined with vitamin B6, mecobalamin, nifedipine sustained release tablets for the treatment of Hypertension clinical curative effect, can improve the patient’s blood pressure and reduce plasma Hcy levels.