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为治疗良性疾病行胃部分切除术后数年,胃残端可发生癌肿,称为残胃癌(GRC)。对其原因有多种解释。在一小部分胃癌中曾发现有E-B病毒(EBV)介入且有证据提示为致病性因素。本文报道GRC中EBV参与的观察结果。 收集48例日本GRC病人的石蜡包埋组织切片。其中男42例,女6例,5～40年前因非胃癌性原因行胃部分切除术。根据GRC发生部位分为残端(残端及其附近)和贲门(肿瘤位于贲门与残端无关)两种。研究方法采用地高辛标记探针EBER-1原位杂交技术。结果发现48例中13例(27.1％)的癌组织EBER-1阳性。几乎全
In order to treat benign diseases for several years after partial gastric resection, gastric stumps may develop cancer, known as residual gastric cancer (GRC). There are many explanations for its causes. E-B virus (EBV) has been detected in a small proportion of gastric cancers and evidence suggests that it is a causative factor. This article reports the observations of EBV involvement in GRC. Paraffin-embedded tissue sections from 48 Japanese patients with GRC were collected. Among them, 42 were males and 6 were females. Gastric partial resection was performed 5 to 40 years ago for non-gastric cancer. According to the location of GRC, it is divided into stump (stump and its vicinity) and cardia (tumor is independent of stump and stump). The research method uses the DIG-labeled probe EBER-1 in situ hybridization. The results showed that EBER-1 was positive in 13 of the 48 cases (27.1%). Almost all