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应用免疫组织化学ＳＰ方法，研究６４例乳腺癌手术标本中ｎｍ２３的表达及其预后意义。结果显示：原发灶癌组织中ｎｍ２３高表达的乳腺癌，区域淋巴结转移发生率明显低于低表达者（Ｐ＜０．０１）；组织学高分化的乳腺癌或肿瘤最大径≤２ｃｍ者，原发灶ｎｍ２３表达水平较高（均Ｐ＜０．０５）；随着临床病理分期的进展，乳腺癌原发灶中ｎｍ２３表达水平逐渐下降（Ｐ＜０．０１）；高表达的患者术后３年、５年生存率分别６９．４％和５８．７％，明显高于低表达者（４２．９％和２５．０％），Ｐ＜０．０５和Ｐ＜０．０１。以上结果表明，ｎｍ２３在乳腺癌淋巴结转移过程中发挥负性调控作用，并与乳腺癌的组织学分化有关。
Immunohistochemical SP method was used to study the expression of nm23 in 64 specimens of breast cancer and its prognostic significance. The results showed that the incidence of regional lymph node metastasis was significantly lower in breast cancer tissues with high nm23 expression in primary tumor tissues than in those with low expression (P<0.01), and those with high histologically well-differentiated breast cancer or tumors ≤2 cm in diameter. The expression of nm23 in the primary tumor was higher (all P<0.05); with the progression of clinical pathology, the nm23 expression in the primary tumor of breast cancer gradually decreased (P<0.01); The 3-year and 5-year survival rates were 69.4% and 58.7%, respectively, which were significantly higher than those with low expression (42.9% and 25.0%), P<0.05 and P<0.01. The above results indicate that nm23 plays a negative regulatory role in lymph node metastasis of breast cancer and is related to the histological differentiation of breast cancer.