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【目的】探讨泌乳素（PRL ）型垂体腺瘤患者术前术后激素水平变化，以评判手术疗效，指导后续治疗。【方法】回顾性分析了96例内镜下经鼻蝶手术 PRL腺瘤患者的临床资料及治疗方法。测定患者术前、术后3 d的PRL水平，并将其与手术切除程度、肿瘤大小等影响因素进行统计学分析。【结果】96例患者，手术全切80例（833．％），未全切16例（167．％）。其中微腺瘤13例，全切13例，全切率100％，大腺瘤65例，全切62例，全切率954．％，巨大腺瘤18例，全切5例，全切率278．％；肿瘤越小，全切率越高。所有病例术后3 d的PRL水平均较术前有所下降。而未全切组与全切组术后 PRL下降程度相比较全切组下降更明显，且差异有显著性（ P ＜00．5）。【结论】手术治疗可有效降低 PRL腺瘤患者PRL水平，术后PRL下降幅度可反映肿瘤切除程度，可根据术后PRL水平来选择进行药物及放射等后续治疗。“,”Objective]To investigate the change in the Prolactin (PRL) hormone levels between pre‐operation and post‐operation of the pituitary adenomas and to judge the postoperative effects and guidance of subsequent treatment .[Methods]We retrospectively analyzed the clinical data and therapeutic methods of 96 cases for prolactinomas .The PRL levels for adenomas pre‐operative and post‐operation of three days were tested .These results were compared with the re‐moval degree of the adenomas and tumors size in a statistical analysis .[Results]The pituitary adenomas were totally re‐sected in 80 cases (83 3.% ) and partially resected in 16 cases(16 7.% ) .13 cases of micro‐adenomas in 13 patients were to‐tally removed;the total removal rate was 100% .62 cases of macro‐adenomas in 65 patients were totally removed ;the to‐tal removal rate was 95 4.% .Only 5 cases of giant‐adenomas in 18 patients were totally removed ;the total removal rate was 27 8.% .The overall total‐resection rate decreased with increasing tumor size .The levels of PRL in all patients were lower in 3 days after the operation ,demonstrating the efficacy of endoscopic transnasal‐sphenoidal surgery .[Conclusion]The surgical operation can effectively reduce the postoperative level of PRL in patients .The degree PRL levels lowered was reflective on the extent of tumor resection ,and useful in determining the need for further treatment of these tumors postoperatively by chemotherapy and radiotherapy .