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作者选择100例正常女性(30～65岁)作为对照,229例证实为宫颈鳞癌的各期(FIGO)病人作为实验对象,并在放疗后随访176例(其中136例随访30个月,40例复发患者随访9个月)。分别测定患者和对照者的白细胞计数和分类、淋巴细胞亚群、自然杀伤细胞活性、淋巴细胞对四种有丝分裂原的转化反应、刀豆蛋白A(ConA)诱导的抑制细胞活性、白细胞介素-2产物、循环免疫复合物(CIC)以及血清免疫球蛋白。结果发现:五种免疫学变量即CD4+淋巴细胞、CD4/CD8比率、自然杀伤细胞活性、ConA诱导的抑制指数(SI)和CIC随肿瘤负荷的变化而相应变化。当用多元回归和多变量分析处理这些变量时,可建立一诊断指
The study selected 100 normal women (30-65 years old) as control and 229 cases of FIGO patients confirmed as cervical squamous cell carcinoma (SCC) as the experimental subjects, followed by 176 cases after radiotherapy (136 cases were followed up for 30 months, 40 Cases of patients were followed up for 9 months). The white blood cell count and classification, lymphocyte subsets, natural killer cell activity, lymphocyte response to four mitogens, ConA-induced cytostatic activity, interleukin- 2 products, circulating immune complexes (CICs) and serum immunoglobulins. The results showed that the five immunological variables, CD4 + lymphocytes, CD4 / CD8 ratio, natural killer cell activity, ConA-induced inhibition index (SI) and CIC, varied with tumor burden. When multiple variables and multivariate analysis are used to process these variables, a diagnostic indicator can be established