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目的 探讨 8号染色体数目改变在胸水肿瘤细胞检测中的应用。方法 利用 8号染色体着丝粒探针以原位杂交为主要技术 ,对 5 2例胸水标本进行研究。结果 在 31例肺癌胸水癌细胞中 ,8号染色体出现超二倍体 ,4例其他肿瘤患者胸水中肿瘤细胞也出现一定比例的 8号染色体超二倍体。细胞学常规检查胸水未找到癌细胞的 15例中 ,有 12例 8号染色体为二倍体 ,另 3例胸水中出现一定比例的 8号染色体超二倍体 ,其中有 2例经复查涂片中找到少数漏诊的腺癌细胞 ,另 1例正在放疗中。 2例细胞学诊断为可疑癌的胸水中也发现有 8号染色体超二倍体。结论 8号染色体超二倍体对恶性胸水的诊断可能具有重要的参考价值。
Objective To investigate the application of chromosome number 8 change in the detection of pleural effusion tumor cells. Methods Using chromosome 8 centromere probes for in situ hybridization as the main technique, 52 cases of pleural effusions were studied. Results Among the 31 lung cancer cells with pleural effusion, hyperdiploids appeared on chromosome 8, and tumor cells in the pleural effusion of other tumors also showed a certain proportion of chromosome 8 hyperdiploids. Of the 15 routine cytology routine examinations for which no pleural effusion cancer cells were found, 12 cases had chromosome 8 diploid, and the other 3 cases had a certain proportion of chromosome 8 hyperdiploids in the pleural effusion, of which 2 cases were reviewed for smears. A few of the missed adenocarcinoma cells were found, and another one was in radiotherapy. Two chromosome hyperdiploids were also found in 2 pleural fluids with cytological diagnosis of suspected cancer. Conclusion The diagnosis of malignant pleural effusion may have important reference value for chromosome 8 hyperdiploid.