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目的:评价舍尼亭联合α受体阻滞剂治疗良性前列腺增生伴逼尿肌过度活动的有效性及安全性。方法:将113例良性前列腺增生伴逼尿肌过度活动患者随机分为A、B两组,A组联合应用舍尼亭(4 mg,1次/d)及可多华(4 mg,1次/d);B组单独使用可多华,治疗时间为12周,记录并比较治疗前后两组患者平均24 h排尿次数、IPSS及QOL评分、最大尿流率、残余尿量及尿潴留次数。结果:治疗后A组平均24 h排尿次数、IPSS及QOL评分改善较B组明显[(3.9±1.25vs2.6±1.37)、(4.4±1.27vs2.2±0.91)、(1.8±1.04)vs(0.5±0.26),P均<0.05];最大尿流率、残余尿量变化两组没有明显差异,两组病例均未发生尿潴留。结论:舍尼亭联合α受体阻滞剂能有效缓解良性前列腺增生伴逼尿肌过度活动患者的排尿困难及尿频、尿急等症状,联合用药后未发现舍尼亭对患者最大尿流率、残余尿量的影响,不增加急性尿潴留的发生率。
OBJECTIVE: To evaluate the efficacy and safety of sebamil plus alpha-blocker in the treatment of hyperplasia of the prostate with detrusor overactivity. Methods: A total of 113 patients with benign prostatic hyperplasia and detrusor overactivity were randomly divided into A and B groups. A group was treated with combination of corticosteroids (4 mg once daily) and ctopidine (4 mg once daily) / d); Group B alone can be more China, the treatment time was 12 weeks, before and after treatment records and compared the average 24 h urination frequency, IPSS and QOL score, maximum flow rate, residual urine volume and urinary retention times. Results: The mean urinary frequency, IPSS and QOL score in group A were significantly higher than those in group B [(3.9 ± 1.25 vs 2.6 ± 1.37), (4.4 ± 1.27 vs 2.2 ± 0.91) vs (1.8 ± 1.04 vs (0.5 ± 0.26), P <0.05]. There was no significant difference between the maximum flow rate and residual urine volume in the two groups. Urinary retention did not occur in both groups. Conclusion: The combination of sebamil and α-blocker can effectively relieve dysuria, urinary frequency and urinary urgency in patients with benign prostatic hyperplasia (BPP) and detrusor overactivity. After combination therapy, the maximal urinary flow rate , The impact of residual urine volume, does not increase the incidence of acute urinary retention.