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目的:采用Meta分析系统评价雄激素受体(AR)基因CAG串联重复多态性与男性不育的关系。方法:检索Medline、CBM等数据库中有关AR基因CAG重复数与男性不育相关性的病例对照研究,并用RevMan4.2软件进行统计分析。结果:共纳入32篇符合条件的文献,累计特发性不育病例3153例、对照2314例。数据合并结果显示,男性不育、无精子症及中度少精子症者其CAG重复数均数均显著高于对照人群(P<0.01),三者与对照间CAG重复数均数的标准均数差分别为0.27,95%CI:0.17～0.37;0.29,95%CI:0.08～0.50;0.27,95%CI:0.13～0.41。而且,敏感性分析结果也与以上研究结果一致。结论:AR基因CAG重复多态性其重复数增多与精子发生障碍的风险相关。
OBJECTIVE: To evaluate the relationship between the CAG tandem repeat polymorphism of androgen receptor (AR) gene and male infertility using meta-analysis system. Methods: A case-control study of the association between CAG repeat of AR gene and male infertility in the database of Medline and CBM was searched and analyzed by RevMan 4.2 software. Results: A total of 32 eligible articles were included, with a total of 3153 cases of idiopathic infertility and 2314 cases of control. The results of data fusion showed that the average numbers of CAG repeat in male infertility, azoospermia and moderate oligospermia were significantly higher than those in control group (P <0.01). The average number of CAG repeat between the three groups was The difference was 0.27, 95% CI: 0.17 to 0.37; 0.29, 95% CI: 0.08 to 0.50; 0.27, 95% CI: 0.13 to 0.41. Moreover, the sensitivity analysis results are consistent with the above findings. CONCLUSIONS: The CAG repeat polymorphism in the AR gene is associated with an increased risk of spermatogenesis disorder.