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目的:研究Wnt信号通路的中GS蛋白(谷氨酰胺合成酶)在胃癌组织中的表达,探索其在胃癌发生、发展中的意义。方法:用免疫组织化学法测定胃癌组织(110例)、肠化生组织(30例)、不典型增生组织(20例)及慢性浅表性胃炎组织(60例)中GS蛋白表达。用快速尿素酶法与病理组织切片染色法检测上述各组织中HP感染的情况,并予统计学分析比较其差异。结果:胃癌组织GS高蛋白表达与组织分型、分化程度、淋巴结转移密切相关(P<0.05),与肿瘤大小、部位、TNM分期、Borrmann分型、性别、年龄等无明显相关(P>0.05)。GS表达与HP感染密切相关。结论:GS蛋白高表达同胃癌生物学行为密切相关,在胃癌的发生、发展中起重要作用。
Objective: To investigate the expression of glutathione synthetase (GS protein) in Wnt signaling pathway in gastric cancer and to explore its significance in the development and progression of gastric cancer. Methods: The expressions of GS protein in gastric cancer (110 cases), intestinal metaplasia (30 cases), atypical hyperplasia (20 cases) and chronic superficial gastritis (60 cases) were detected by immunohistochemistry. Rapid urease and histological sections were used to detect the HP infection in the above tissues, and the differences were statistically analyzed. Results: The expression of GS protein in gastric carcinoma was closely related to the histological type, differentiation and lymph node metastasis (P <0.05), but not to the tumor size, location, TNM stage, Borrmann type, sex, age, ). GS expression is closely related to HP infection. Conclusion: The high expression of GS protein is closely related to the biological behavior of gastric cancer and plays an important role in the occurrence and development of gastric cancer.