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目的：了解ｒａｓ和ｅｒｂＢ２基因在肺癌中表达的临床意义。方法：采用免疫组化技术研究了ｒａｓｐ２１和ｅｒｂＢ２ｐ１８５在４０例肺癌（腺癌１９例，鳞癌１８例，腺鳞癌１例，小细胞肺癌２例）中的表达，并将肺癌按临床病理特征分组进行对比分析。结果：①在非小细胞肺癌（ＮＳＣＬＣ）中，ｐ２１的阳性率为６１％，ｐ１８５的阳性率为４２％，２例小细胞肺癌（ＳＣＬＣ）均无ｐ２１和ｐ１８５的表达。②ｐ１８５在肺腺癌中的表达明显高于鳞癌（Ｐ＜０．０５）。③在ＮＳＣＬＣ中，ｐ２１在Ⅰ～Ⅱ期中的阳性率为２５％，Ⅲａ～Ⅲｂ期中的阳性率为７７％，两者有非常显著的差异（Ｐ＜０．０１）。④ｐ２１和ｐ１８５阳性的ＳＮＣＬＣ患者，其淋巴结转移发生早，速度快（Ｐ＜０．０５）。⑤ｐ１８５在ＳＮＣＬＣ中的表达存在性别差异，女性明显高于男性（Ｐ＜０．０１）。结论：ｒａｓ和ｅｒｂＢ在ＮＳＣＬＣ中的表达具有重要的临床意义。
Objective: To understand the clinical significance of ras and erbB2 gene expression in lung cancer. Methods: The expression of rasp21 and erbB2p185 in 40 cases of lung cancer (adenocarcinoma 19 cases, squamous cell carcinoma 18 cases, adenosquamous carcinoma 1 case, and small cell lung cancer 2 cases) were studied by immunohistochemical technique. Grouping for comparative analysis. Results: 1 In non-small cell lung cancer (NSCLC), the positive rate of p21 was 61%, and the positive rate of p185 was 42%. There was no expression of p21 and p185 in 2 cases of small cell lung cancer (SCLC). The expression of 2p185 in lung adenocarcinoma was significantly higher than that in squamous cell carcinoma (P<0.05). 3 In NSCLC, the positive rate of p21 in stage I-II was 25%, and the positive rate in stage IIIa-IIIb was 77%. There was a very significant difference between the two (P<0.01). In patients with 4p21 and p185 positive SNCLC, lymph node metastasis occurred earlier and faster (P<0.05). There was a gender difference in the expression of 5p185 in SNCLC, which was significantly higher in women than in men (P<0.01). Conclusion: The expression of ras and erbB in NSCLC has important clinical significance.