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本研究通过动物实验和临床观察,对比几种不同类型的迷走神经切断(迷切)手术对胃粘膜组织学和胃酸分泌功能的影响。结果显示,不附加胃窦切除的几种迷切手术,术后降酸程度是类似的,BAO降低60～80％,MAO降低50～70％,而附加胃窦切除后,降酸程度更明显,胃酸的降低程度可以使溃疡愈合。 迷切手术本身未引起胃粘膜组织学变化,而附加了破坏幽门括约肌功能的手术,可引起胃粘膜炎症的进行性加重,尤其是胃窦部和吻合口周围,提示与胆汁返流有密切关系,但与术后降酸程度无关。本实验也未发现术后胃酸分泌功能抑制的组织学依据,术后胃酸降低可能与单个壁细胞功能的抑制有关。
In this study, animal experiments and clinical observations were performed to compare the effects of several different types of vagotomy (fagotomy) on histological and gastric acid secretion. The results showed that the degree of acid deprivation after surgery was similar for those who did not add gastric antrum resection. The BAO was reduced by 60-80% and the MAO was reduced by 50-70%. After the addition of antral excision, the degree of acid reduction was more obvious. The degree of gastric acid reduction can heal ulcers. Conservative surgery itself does not cause changes in the gastric mucosal histology, but surgery to destroy the pyloric sphincter function can cause progressive increase in inflammation of the gastric mucosa, especially around the gastric antrum and anastomosis, suggesting a close relationship with bile reflux. , but it has nothing to do with the degree of acid reduction after surgery. This experiment also did not find the histological basis for inhibition of gastric acid secretion after surgery. Postoperative gastric acid reduction may be related to inhibition of single parietal cell function.