内质网(endoplasmic reticulum,ER)是细胞内最重要的细胞器之一,内质网功能与细胞状态密切相关。异常蛋白在内质网内堆积、钙离子代谢紊乱、胆固醇代谢异常等均导致内质网应激,内质网应激在细胞生理病理中发挥重要作用。研究表明内质网应激与中毒相关性疾病关系密切,该文简要概述了内质网应激与中毒之间的关系。 Endoplasmic reticulum (endoplasmic reticulum, ER) is one of the most important intracellular organelles, endoplasmic reticulum function and cell status are closely related. Abnormal protein accumulation in the endoplasmic reticulum, calcium metabolism disorder, abnormal cholesterol metabolism lead to endoplasmic reticulum stress, endoplasmic reticulum stress plays an important role in cell physiology and pathology. Studies have shown that endoplasmic reticulum stress and poisoning-related diseases are closely related, the paper briefly outlined the relationship between stress and endoplasmic reticulum stress.