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AIM:To establish an ideal implantable rat liver tumor modelfor interventional therapy study and examine its angiographicsigns and MRI,CT features before and after embolization.METHODS:Forty male Wistar rats were implanted with Walker-256 tumor in the left lateral lobe of liver.Digital subtractionangiography(DSA)and transarterial chemoembolization wereperformed on day 24 after implantation.Native computertomography(CT,n=8)and native magnetic resonance(MR,n=40)were performed between the day 8 and day 22 afterimplantation.The radiological morphological characteristics werecorrelated with histological findings.RESULTS:Successful implantation was achieved in all fortyrats,which was confirmed by CT and MRI.MR allowed tumorvisualization from day 8 while CT from day 22 after implantation.The tumors were hypodensity on CT,hypointense on MR T1-weighted and hyperintense on T2-weighted.The model closelyresembled human hepatocarcinoma in growth pattem and thelesions were rich in vasculature on angiography and got itsfilling mainly from the hepatic artery.Before therapy,tumorsize was 221.9±48.7 mm~3,No ascites,satellite liver nodulesor lung metastasis were found.One week after therapy,tumorsize was 963.6±214.8 mm~3 in the control group and 356.5±78.4mm~3 in TACE group.Ascites(4/40),satellite liver nodules(7/40)or lung metastasis(3/40)could be seen on day 22.CONCLUSION:Walker-256 tumor rat model is suitable forthe interventional experiment.CT and MRI are helpful inanimal optioning and evaluating experimental results.
AIM: To establish an ideal implantable rat liver tumor model for interventional study study and examine its angiographic signs and MRI, CT features before and after embolization.METHODS: Forty male Wistar rats were implanted with Walker-256 tumor in the left lateral lobe of liver.Digital Subtractionangiography (DSA) and transarterial chemoembolization wereperformed on day 24 after implantation. Native computertomography (CT, n=8) and native magnetic resonance (MR, n=40) were performed between the day 8 and day 22 afterimplantation. The radiological morphological characteristics were correlated. With histological findings.RESULTS:Successful implantation was achieved in all fortyrats, which was confirmed by CT and MRI.MR allowed tumor visualization from day 8 while CT from day 22 after implantation.The tumors were hypodensity on CT,hypointense on MR T1-weighted and Hyperintense on T2-weighted.The model closelyresembled human hepatocarcinoma in growth pattem and thelesions were rich in vasculature on angi Ography and got its fillinging mainly from the hepatic artery.Before therapy,tumorsize was 221.9±48.7 mm~3,No ascites,satellite liver nodulesor lung metastasis were.One week after therapy,tumorsize was 963.6±214.8 mm~3 in the control group And 356.5±78.4mm~3 in TACE group.Ascites(4/40),satellite liver nodules(7/40)or lung metastasis(3/40)could be seen on day 22.CONCLUSION:Walker-256 tumor rat model is Suitable forthe interventional experiment.CT and MRI are helpful in animalily optioning and evaluating experimental results.