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目的对比观察米非司酮配伍米索前列醇阴道给药及舌下含服对早早期妊娠的药物流产效果。方法将70例停经妇女(停经≤37d)随机分为两组,第1天均顿服米非司酮150mg,第3天(服米非司酮36～48h后)使用米索前列醇,分为阴道给药400μg(组Ⅰ)和舌下含服400μg(组Ⅱ)两种方式以终止妊娠。结果总完全流产率为92.86%,其中组Ⅰ为97.06%,组Ⅱ为88.89%,两组比较有显著性差异(P<0.05);两组均无不全流产发生;总失败率为7.14%,其中组Ⅰ为2.94%,组Ⅱ为11.11%,两组比较有显著性差异(P<0.05);70例患者血hCG值与药物流产后的出血时间成显著正相关(P=0.000)。结论对于停经37d以内的早早孕终止妊娠,米非司酮配伍米索前列醇阴道给药能达到更好的药物流产效果,不完全流产率极低,但要警惕异位妊娠的可能。
Objective To compare the efficacy of mifepristone with misoprostol vaginal administration and sublingual administration on early pregnancy induced abortion. Methods Seventy women with menopause (menopause ≤37d) were randomly divided into two groups. The first day were treated with mifepristone 150mg. On the third day (after mifepristone 36-48h), misoprostol was used For the vaginal administration of 400μg (group Ⅰ) and sublingual 400μg (group Ⅱ) two ways to terminate the pregnancy. Results The total complete abortion rate was 92.86%, of which 97.06% in group I and 88.89% in group II were significantly different between the two groups (P <0.05). The total abortion rate was 7.14% There were significant differences between the two groups (P <0.05). The blood hCG levels in 70 patients were positively correlated with the bleeding time after medical abortion (P = 0.000). Conclusion For early pregnancy termination of pregnancy within 37d after menopause, vaginal administration of mifepristone and misoprostol can achieve better effect of medical abortion, incomplete abortion rate is very low, but to guard against the possibility of ectopic pregnancy.