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目的 探讨尿激酶(UK)和前列腺素(PGE1)联合给药对急性心肌梗死(AMI)6h内入院患者进行静脉溶栓的疗效观察。方法 分为UK+PGE1组(32例)及UK组(49例);UK用量为2万U/kg,PGE1用量为300～400μg/次。两组年龄、性别、发病至用药时间均无差异。结果 联用组再通23例,再通率71.9%;再阻塞2例,再阻塞率8.7%;住院死亡2例,病死率6.2%。单用UK组上述分别为28例(57.1%);6例(21.4%);5例(10.2%)。结论 联用组比单用组再通率高,而再阻塞率及住院病死率明显降低。并且PGE1未增加UK出血之发生,且PGE1副作用小,为安全、有效药物。
Objective To investigate the curative effect of intravenous thrombolysis combined with urokinase (UK) and prostaglandin (PGE1) on patients hospitalized within 6 hours after acute myocardial infarction (AMI). Methods: The UK + PGE1 group (n = 32) and the UK group (n = 49) were included. The dose of UK was 20000U / kg and the dosage of PGE1 was 300-400μg / time. Two groups of age, gender, incidence to medication time no difference. Results In the combined group, 23 cases were recanalized and the recanalization rate was 71.9%. Two cases were obstructed and the reocclusion rate was 8.7%. Two cases were hospitalized and the case fatality rate was 6.2%. In the UK group alone, 28 (57.1%) were described above; 6 (21.4%) and 5 (10.2%) patients, respectively. Conclusions The combined group has a higher rate of recanalization than the single group, while the rate of reocclusion and in-hospital mortality is significantly lower. And PGE1 did not increase the occurrence of UK bleeding, and PGE1 side effects, as safe and effective drug.