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目的:研究Hedgehog信号通路相关基因SHH、SMO、GLI_1在大肠癌中的表达及其临床意义。方法:用RT-PCR检测43例大肠癌切除标本的癌组织和距离癌10 cm以上的癌旁组织的SHH、SMO、GLI_1 mRNA表达的阳性率,并与20例非肠癌患者的正常大肠组织对照,分析其与大肠癌患者临床和病理各变量的相关性。结果:大肠癌组织SHH mRNA表达阳性率为27.9%,与癌旁组织的18.6%比较,差异无显著性(p>0.05),但显著高于正常组织的0%(P<0.05)。大肠癌组织SMO、GLI_1 mRNA表达阳性率分别为83.7%、34.9%,显著高于癌旁组织的58.1%、16.3%及正常组织的0%、0%(P<0.05)。SHH、SMO、GLI_1 mRNA表达阳性率之间并无相关性,阳性率与患者的年龄、性别、临床分期、肿瘤部位、肿瘤浸润深度、病理分型等变量均无相关性(P>0.05)。结论:Hedgehog信号通路相关基因SHH、SMO、GLI_1 mRNA在大肠癌组织中表达阳性率显著增高,其表达与临床和病理各变量不相关。
Objective: To study the expression of Hedgehog signaling pathway related genes SHH, SMO, GLI_1 in colorectal carcinoma and its clinical significance. Methods: The positive rates of SHH, SMO and GLI_1 mRNA expression in 43 cases of colorectal cancer resected specimens and adjacent non-cancerous tissues more than 10 cm away from cancer were detected by RT-PCR, and compared with 20 cases of normal colorectal tissues Control, analysis of colorectal cancer patients with clinical and pathological variables related. Results: The positive rate of SHH mRNA in colorectal cancer was 27.9%, which was significantly higher than that in normal tissues (p> 0.05), but not significantly different from that in normal tissues (p> 0.05). The positive rates of SMO and GLI_1 mRNA in colorectal cancer tissues were 83.7% and 34.9%, respectively, which were significantly higher than those in adjacent tissues (58.1% and 16.3%, 0% and 0%, respectively). The positive rates of SHH, SMO and GLI_1 mRNA had no correlation with the age, sex, clinical stage, tumor location, depth of tumor invasion and histopathological type (P> 0.05). CONCLUSION: The positive rates of Hedgehog signaling pathway related genes SHH, SMO and GLI_1 mRNA in colorectal cancer tissues are significantly higher than those in clinical and pathological variables.