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在动物模型中,近交系小鼠感染利什曼原虫出现截然不同的易感性。决定感染是否自愈的宿主反应虽不清楚,但细胞因子产生的选择性与小鼠感染有关。在大型利什曼原虫易感的BALB/c小鼠主要是T_H2并产生IL-4和IL-10,而在不易感的C57BL/6小鼠主要为T_H1并分泌IFN-γ和IL-2。IFN-γ是与抗利什曼原虫感染最密切的细胞因子,而IL-4与易感性有关。β-生长转化因子(TGF-β)是多种细胞产生的24kDa
In animal models, inbred mice infected with Leishmania showed distinctly different susceptibilities. Although the host response to determine whether the infection self-healing is not clear, but the selectivity of cytokine production and mouse infection. BALB / c mice susceptible to large Leishmania are predominantly T_H2 and produce IL-4 and IL-10, whereas predisposing C57BL / 6 mice are predominantly T_H1 and secrete IFN-γ and IL-2. IFN-γ is the most closely associated cytokine to Leishmania infection, whereas IL-4 is associated with susceptibility. Beta-growth transforming factor (TGF-beta) is a 24 kDa produced by a variety of cells