论文部分内容阅读
将２，７－二羰烷氧基萘（２）在三氯氧磷中环化成７３％不对称及２７％对称的四甲基萘并二呋喃（４和５）。在盐酸作用下２环化成３，随后在乙酰乙酸乙酯／二氯甲烷中及三溴化硼作用下生成区域选择性环化产物（５）。采用荧光强度测定法发现４对小牛胸腺ＤＮＡ有嵌入作用。分子模拟方法指出４与５在ＤＮＡ嵌入性能上的差别主要是由它们分子平面性不同所致。
The 2,7-dicarbonylalkoxynaphthalene (2) was cyclized in phosphorus oxychloride to 73% asymmetric and 27% symmetrical tetramethylnaphthandiumbrofuran (4 and 5). The cyclization of 2 to 3 under the action of hydrochloric acid followed by the formation of a regioselective cyclization product (5) in ethyl acetoacetate / dichloromethane and boron tribromide. Fluorescence intensity assay was used to detect 4 pairs of calf thymus DNA. The molecular modeling method indicates that the difference between 4 and 5 in DNA insertion performance is mainly caused by their different molecular planarity.