[目的]比较国内4个厂家米索前列醇片在4种不同pH值溶出介质中的溶出曲线相似性.[方法]采用《中国药典》(2015年版)溶出度测定法第2法,分别以pH值为1.2的盐酸溶液、pH值为4.5和6.8的磷酸盐缓冲液和水为溶出介质,利用HPLC法测定溶出量并绘制4个厂家米索前列醇片的体外溶出曲线,采用f2相似因子法考察相似性.[结果]A与B厂家同原研制剂溶出曲线存在明显差异,C与D厂家同原研制剂溶出曲线相近.[结论]不同厂家的辅料、生产工艺和规模的不同导致了米索前列醇片溶出度的差异. [Objective] To compare the dissolution curve similarity of misoprostol tablets in 4 different pH dissolution media in 4 domestic manufacturers. [Methods] The dissolution method of Chinese Pharmacopoeia (2015 edition) hydrochloric acid solution with pH value of 1.2, phosphate buffer solution with pH values ​​of 4.5 and 6.8 and water as dissolution medium, the dissolution amount was determined by HPLC and the in vitro dissolution curve of misoprostol tablets of four manufacturers was drawn, and the f2 similarity factor Method was used to investigate the similarity. [Result] The dissolution curves of A and B were the same as those of B and D, and the dissolution curves of C and D were similar to that of the original preparation. [Conclusion] The different materials, production technologies and scales of different manufacturers led to miso Differences in prothrombin dissolution.