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Objective:To investigate antidiabetic potential of alcoholic leaves extract ofAlangium lamarckii (A. lamarckii) on streptozotocin-nicotinamide induced type2 diabetic rats.Methods: Oral glucose tolerance test was done by inducing hyperglycemic state via administration of glucose in water (2 g/kg). Single dose of alcoholic leaves extract ofA. lamarckii(250and500 mg/kg,p.o.) were administered to normoglycemic, hyperglycemic rats. Type 2 diabetes was induced by single intraperitoneal injection of nicotinamide (110 mg/kg) followed by streptozotocin (65 mg/kg). The study also included estimations of blood plasma glucose, lipid profile, liver glycogen, body weight and antioxidant status in normal and diabetic rats.Results: Admistration of alcoholic extract ofA. lamarckii at two dosage250 and500 mg/kg,p.o. did not showed any significant change in blood glucose level of normoglycemic rats (P>0.05), whereas, oral glucose tolerance test depicted reduction in blood glucose level (P<0.05). The streptozotocin-nicotinamide induced diabetic rats, significantly decreased the blood plasma glucose level (P<0.001) comparable to glibenclamide (10 mg/kg), restored the lipid profile and showed improvement in liver glycogen, body weight and antioxidant status in diabetic rats.Conclusions: Present finding demonstrated the significant antidiabetic activity of alcoholic leaves extract ofA. lamarckii.