The effect of interaction among γ′ ordered domains on the interdiffusion process in γ + γ′/γ and γ + γ′/γ + γ′ diffusion couples is investigated by using the phase-field method, in which bulk free energy and mobility are linked with thermodynamic and kinetic databases. Simulated results show that the interaction among γ′ ordered domains has great influence on the microstructure, the interdiffusion velocity and the volume fraction of γ′ phase on both sides of the diffusion couples. The effect of interaction among γ ’ordered domains on the interdiffusion process in γ + γ’ / γ and γ + γ ’/ γ + γ’ diffusion couples is investigated by using the phase-field method, in which bulk free energy and mobility are linked with thermodynamic and kinetic databases. Simulated results show that the interaction among γ ’ordered domains has great influence on the microstructure, the interdiffusion velocity and the volume fraction of γ’ phase on both sides of the diffusion couples.