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商陆Phytolacca esculenta的根,作为传统中药可治肿瘤、水肿及慢性支气管炎。其总皂甙除有抗炎作用外,还有明显的诱生免疫干扰素(IFN-T)及肿瘤坏死因子(TNF)活性。作者曾从该植物根中分离出9种皂甙。本文报导用含皂甙的乙醇提取物在氯仿-水中分配,氯仿提取物经重复硅胶柱层析及重结晶,分到一种新三萜商陆精酸(esculenta-genic acid)(1)。商陆根的甲醇提取物经硅胶柱层析,用氯仿-甲醇-水(7:3:0.3)洗脱,收集相应的部位,然后经半制备HPLC,用
Phytolacca esculenta roots of Pokeweed as a traditional Chinese medicine can treat tumors, edema, and chronic bronchitis. In addition to its anti-inflammatory effects, total saponins also have significant induced immune interferon (IFN-T) and tumor necrosis factor (TNF) activity. The authors isolated 9 saponins from the plant roots. This paper reports that the ethanol extract containing saponin was partitioned in chloroform-water, and the chloroform extract was purified by repeated silica gel column chromatography and recrystallization to give a novel triterpenoid esculenta-genic acid (1). The methanol extract of psyllium root was subjected to silica gel column chromatography and eluted with chloroform-methanol-water (7:3:0.3), the corresponding site was collected, and then semi-preparative HPLC was used.