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目的评价甲地孕酮在食道癌患者放疗中,减轻消化道反应,改善患者生活质量的作用。方法对照组39例给予常规放疗,治疗组41例在对照组基础上给予甲地孕酮(160mg/d)观察两组消化道反应及生活质量情况。结果治疗组消化道反应发生率低于对照组(P<0.01);治疗组患者生活质量改善优于对照组(P<0.01)。未见甲地孕酮所致的严重毒副作用。结论甲地孕酮对接受放疗的食管癌患者在减轻消化道反应和提高生活质量方面有明显作用。
Objective To evaluate the role of megestrol in patients with esophageal cancer radiotherapy, reduce gastrointestinal reactions and improve the quality of life of patients. Methods 39 patients in the control group were given conventional radiotherapy. 41 patients in the treatment group were treated with megestrol (160mg / d) on the basis of the control group, and the gastrointestinal reactions and quality of life were observed. Results The incidence of digestive tract reaction in the treatment group was lower than that in the control group (P <0.01). The quality of life of the treatment group was better than that of the control group (P <0.01). No serious side effects caused by megestrol. Conclusion Megestrol has a significant effect on reducing gastrointestinal reactions and improving quality of life in esophageal cancer patients undergoing radiotherapy.