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给予血卟啉衍生物(Hematoporphyrin derivative,简称HpD)之后用激光照射某些恶性肿瘤是近年来开展的新方法之一,受到国内外医药界的重视。但由于激光穿透组织的能力是按穿透深度的负指数函数衰减的,即使使用穿透力较强的6300A°氦氖激光,当单束光穿透2cm深度后,其强度也仅为原来的万分之一。用氩离子激光泵浦的染料激光器,经光导内窥镜照射狗的支气管癌,光线穿透的深度从表层起,只有5mm左右。因此对大多数深部肿瘤不能用光敏疗法来治疗。 1966年Cohen等用血卟啉(Hematoporphyrin)加X线治疗鼠腿肿瘤,发现仅对个别血卟啉剂量有增敏作用。近几年陈定一等报
The application of hematoporphyrin derivative (HpD) to the irradiation of certain malignant tumors with laser light is one of the new methods developed in recent years, and has attracted the attention of the medical community at home and abroad. However, because the ability of the laser to penetrate the tissue is attenuated by the negative exponential function of the penetration depth, even if the 6300A° helium laser with strong penetrating power is used, when the single beam penetrates the depth of 2cm, the intensity is only the original. One ten thousandth. A dye laser pumped by an argon ion laser irradiates a dog’s bronchial carcinoma with a light-guided endoscope, and the penetration depth of light is only about 5 mm from the surface layer. Therefore, most of the deep tumors cannot be treated with phototherapy. In 1966, Cohen et al. used hematoporphyrin plus X-ray to treat rat leg tumors and found that there was only a sensitization effect on the dose of individual hematoporphyrins. In recent years, Chen Dingyi et al.