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以色氨酸和氘水及色氨酸和氯化氘两种交换反应合成氘标色氨酸，其产率分别为95％和92％，氘标总丰度分别为96．2％和98．5％。以色氨酸和氘水反应合成的氘标色氨酸为原料，经环化、氧化脱羧及水解等反应合成氘标川芎哚，产率为11．6％，氘标总丰度约为90％。结果表明，合成的氘标川芎哚满足药物代谢研究的需要。
The tryptophan was synthesized using tryptophan and hydrazine water, and tryptophan and cesium chloride. The yields were 95% and 92%, respectively. The total abundance of target was 96.2% and 98%, respectively. .5%. The tryptophan-tryptophan synthesized by the reaction of tryptophan and hydrazine was used as the raw material to synthesize S. sichuanense by the cyclization, oxidative decarboxylation and hydrolysis reaction. The yield was 11.6%, and the total abundance of target was about 90. %. The results showed that the synthesized B. chuanxiong meets the needs of drug metabolism research.