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目的研究磷酸化组蛋白H3(PHH3)在乳腺浸润性导管癌中的表达,探讨PHH3在乳腺癌组织学分级中的价值及其临床意义。方法应用免疫组化En Vision法研究85例浸润性导管癌中PHH3的表达。结果 PHH3标记的核分裂指数与HE染色下的核分裂指数具有很好的相关性,PHH3标记的核分裂指数高于HE染色下的核分裂指数。基于PHH3染色的核分裂指数,1例由组织学分级Ⅰ级上升到Ⅱ级,4例由组织学分级Ⅱ级上升到Ⅲ级。PHH3标记的高分裂指数与组织学分级和淋巴结转移有关(P<0.05),而与患者年龄、肿瘤部位和大小无关(P>0.05)。结论 PHH3是一种更好的标记核分裂象的标记物,可提高乳腺浸润性导管癌组织学分级的准确性,从而更好地指导临床治疗。
Objective To investigate the expression of phosphorylated histone H3 (PHH3) in invasive ductal carcinoma of the breast and to investigate the value of PHH3 in the histological grade of breast cancer and its clinical significance. Methods Immunohistochemical En Vision method was used to study the expression of PHH3 in 85 cases of invasive ductal carcinoma. Results There was a good correlation between the mitotic index of PHH3 labeling and the mitotic index of HE staining. The index of mitotic index of PHH3 labeling was higher than that of HE staining. According to PHH3 staining, the index of fission increased from grade Ⅰ to grade Ⅱ in one case and from grade Ⅱ to grade Ⅲ in 4 cases. The PHH3-labeled high-mitotic index was associated with histological grade and lymph node metastasis (P <0.05), but not with patient age, tumor location and size (P> 0.05). Conclusion PHH3 is a better marker of mitosis, which can improve the accuracy of histological grading of invasive ductal carcinoma of the breast and guide the clinical treatment.