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干扰素(IFN)和 IFN 诱导剂抑制实验动物肝混合功能氧化酶(MFO)活性。病毒感染、流感疫苗和卡介苗接种也影响药物代谢,可能通过产生 IFN 而致。α-IFN 降低人体对安替比林和茶碱的廓清率。本文报告α-IFN对人体肝脏药物代谢的影响。12例慢性活动性乙型肝炎患者(9男,3女,年龄17～39岁),使用α-IFN 治疗,剂最为6×10~6U,肌注,共4周。治疗前后在超声波指示下活组织穿刺,获得肝组织进行组织学检查和检测药物代谢活性。在选择病例时要剔除曾服用诱导或抑制药物代谢酶的药物的
Interferon (IFN) and IFN-inducing agents inhibited hepatic mixed-function oxidase (MFO) activity in experimental animals. Viral infections, flu vaccination, and BCG vaccination also affect drug metabolism, possibly by producing IFN. α-IFN reduces the body’s clearance of antipyrine and theophylline. This article reports the effects of alpha-IFN on human liver drug metabolism. Twelve patients with chronic active hepatitis B (9 males and 3 females, aged 17-39 years) were treated with α-IFN at a dosage of 6 × 10-6 U intramuscularly for 4 weeks. Before and after treatment under the guidance of ultrasound biopsy to obtain liver tissue for histological examination and detection of drug metabolism activity. In the choice of cases to be removed when the drug has been taken to induce or inhibit drug-metabolizing drugs