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黄曲霉毒素M_1(AFTM_1)是哺乳动物摄入黄曲霉毒素B_1(AFT B_1)后在体内经羟基化代谢后的产物,可在乳汁中检出。由于其在化学结构上与AFTB_1的相似性,因此仍是一种潜致癌物。虽然其致癌致变性不及AFT B_1,但其急性毒性仍与AFTB_1相当,因此一般都认为不允许在牛奶或奶粉中存在。这对哺乳期婴幼儿尤为重要。目前有的国家已制定了有关法规加以限制。1984年胡氏等曾作过上海市婴儿AFT M_1摄入量调查,本文采用更灵敏、简便、可靠的反相HPLC法对市区居民食用的牛奶和奶粉中AFTM_1含量进行测定并用卡方检验法处理牛奶样品,分析其季节性和居民区间的统计学差异。
Aflatoxin M_1 (AFTM_1) is a product of hydroxylation of aflatoxins B_1 (AFT B_1) in mammals and can be detected in milk. Because of its chemical structure and AFTB_1 similarity, it is still a potential carcinogen. Although its carcinogenic degeneration is less than that of AFT B_1, its acute toxicity is still comparable to that of AFTB_1, so it is generally considered not to be present in milk or milk powder. This is particularly important for breastfeeding infants. At present, some countries have enacted laws and regulations that restrict them. In 1984, Hu et al. Conducted a survey of infant AFT M_1 intake in Shanghai. In this paper, the more sensitive, simple and reliable reversed-phase HPLC method was used to determine the AFTM_1 content of milk and milk powder consumed by urban residents and the chi-square test Milk samples were processed and analyzed for seasonal and residential differences.