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神经精神性狼疮(NPSLE)是系统性红斑狼疮(SLE)的严重并发症,其临床表现复杂多样,主要表现为头痛、癫痫、脑血管病、认知障碍、抑郁、焦虑。NPSLE可发生于SLE病程的任何阶段,其可能的发病机制是多方面的,包括自身抗体的产生、微血管病变以及炎性介质的参与。对于NPSLE诊断,国际上尚无统一的标准,必须综合运用免疫血清学检查、神经影像学检查及神经精神的评估。其治疗主要包括免疫抑制,对症治疗以及抗凝治疗。
Neuropathic lupus (NPSLE) is a serious complication of systemic lupus erythematosus (SLE). Its clinical manifestation is complex and diverse, mainly manifested as headache, epilepsy, cerebrovascular disease, cognitive impairment, depression and anxiety. NPSLE can occur at any stage of SLE’s course of disease, its possible pathogenesis is multifaceted, including the production of autoantibodies, microvascular lesions, and the involvement of inflammatory mediators. For NPSLE diagnosis, there is no unified international standard, we must comprehensive use of immune serology, neuroimaging and neuropsychological assessment. The treatment includes immunosuppression, symptomatic treatment and anticoagulant therapy.