(一)草酸硫代酰胺乙酯,在丙酮溶剂中,与1,3二氯丙酮起作用,即得2-甲酸乙酯-4-氯甲基噻唑。后者亦可用草酸酰胺乙酯,五硫化二燐和1,3二氯丙酮在甲苯中加热制得。 (二)2-甲酸乙酯-4-氯甲基噻唑溶于無水甲醇与氰化鉀起反应,产生2-甲酸乙酯-4-乙腈噻唑。后者溶于乙醇,在室温情况下,与85％肼起作用,即成2-甲酰腓-4-乙腈噻唑。 (A) thioamide ethyl oxalate, acetone solvent, and 1,3-dichloroacetone work, which was 2-ethyl-4-chloromethyl-thiazole. The latter can also be used oxalate ethyl ester, pentasulfide and 1,3-dichloroacetone heating in toluene obtained. (B) Ethyl 2-carboxylate-4-chloromethylthiazole was dissolved in anhydrous methanol to react with potassium cyanide to give ethyl 2-carboxylate-4-thiazole. The latter is soluble in ethanol, at room temperature with 85% hydrazine role, which is 2-formyl-4-acetonitrile thiazole.